Recent human feeding studies have shown how the baseline taxonomic composition of the gut microbiome can determine responses to dietary interventions, but the exact functional determinants underlying this phenomenon remain unclear. In this study, we set out to better understand interactions between baseline BMI, metabolic health, diet, gut microbiome functional profiles, and subsequent weight changes in a human cohort that underwent a healthy lifestyle intervention. Overall, our results suggest that the microbiota may influence host weight loss responses through variable bacterial growth rates, dietary energy harvest efficiency, and immunomodulation.
Our latest preprint is up, where @thaasophobia looked at baseline multi-omic features from a small human cohort (N=25) to identify potential associations with weight loss success during a lifestyle intervention https://t.co/1oZTX6gye7 @isbsci @sush_pat @ISBLeeHood @ISBNathanPrice
— Sean Gibbons (@gibbological) January 6, 2021