Welcome 👋

We are a lab led by Christian Diener at the Medical University of Graz in the Diagnostic and Research Institute of Hygiene, Microbiology and Environmental Medicine. Our lab studies the human gut microbiome through an approach that combines ecology, systems biology, and metabolism. We are also big fans of equitable and accessible Science and participate in various efforts to share our research, software, and teaching materials.

Like us, microbes rarely live alone and may behave quite differently when around others or in a new environment. We are interested in the complex metabolic interactions taking place between microbes, the host, and their environment, and how those can be leveraged to understand and design complex microbial communities. We mainly use computational strategies but also run experiments in our wetlab.

The lab forms part of the Austrian FWF Cluster of Excellence Microbiomes Drive Planetary Health and collaborates with other researchers and industry all across the globe. If you are interested in learning more feel free to check out our team, lab values, research areas, and publications.

Latest publication

Neonates exposed to HIV but uninfected exhibit an altered gut microbiota and inflammation associated with impaired breast milk antibody function

Background Infants exposed to HIV but uninfected have altered immune profiles which include heightened systemic inflammation. The mechanism(s) underlying this phenomenon is unknown. Here, we investigated differences in neonatal gut bacterial and viral microbiome and associations with inflammatory biomarkers in plasma. Further, we tested whether HIV exposure impacts antibody-microbiota binding in neonatal gut and whether antibodies in breast milk impact the growth of commensal bacteria. Results Neonates exposed to HIV but uninfected (nHEU) exhibited altered gut bacteriome and virome compared to unexposed neonates (nHU).